Safi is an accomplished second-generation physicist, biotech entrepreneur, and former public-company CEO renowned for his expertise in strategy and innovation. He holds a BA summa cum laude from Harvard and a PhD in physics from Stanford, where he worked alongside illustrious figures in the fields of particle physics and condensed matter physics. Following a successful stint with McKinsey, he co-founded a biotechnology company focused on developing groundbreaking cancer drugs, leading it through a successful IPO and serving as CEO for 13 years. Recognized for his achievements, Safi was named E&Y New England Biotechnology Entrepreneur of the Year in 2008 and contributed to President Obama’s council of science advisors (PCAST) on national research in 2011.
Safi’s impact extends beyond the lab and boardroom—it is felt in the realm of literature as well. His first book, “Loonshots,” has garnered international acclaim, translated into 21 languages, and selected as a best business book of the year by notable publications such as Amazon, Bloomberg, Financial Times, Forbes, Inc., and the Washington Post. With glowing recommendations from luminaries like Bill Gates, Daniel Kahneman, Malcolm Gladwell, and many others, the book has left an indelible mark on the business world.
Drawing on his rich experience, Safi advises CEOs and leadership teams on strategy and innovation, delivering captivating keynote presentations at prestigious industry conferences, investor events, leadership retreats, medical meetings, and esteemed academic institutions worldwide. His insightful guidance has propelled organizations to new heights, fostering a culture of innovation and driving meaningful change.
In addition to presenting at Fortune 500 companies including Amazon, Google, Goldman Sachs, Johnson + Johnson, Microsoft, Viacom and others, Safi has presented to or advised hypergrowth startups, investment funds, the CIA, the US Air Force, and the US Navy, as well as spoken at business schools and science, mathematics, or medical departments at Harvard, MIT, Stanford, Princeton, UC Berkeley, Caltech, Cornell, Bell Labs, Dana-Farber Cancer Institute, Massachusetts General Hospital, the National Institutes of Health, and others.
Safi is a member of the MG100 group of senior executive coaches. In addition to speaking and leading workshops, Safi works 1-1 with a small number of CEOs as well as leaders of government agencies on strategy and innovation.
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